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文章摘要
jiangfancheng.Study on HPLC Fingerprint of Qinghouyan Mixture[J].中国药物评价,2019,36(4):271-274
清喉咽合剂高效液相指纹图谱研究
Study on HPLC Fingerprint of Qinghouyan Mixture
投稿时间:2019-04-01  修订日期:2019-05-28
DOI:
中文关键词: 清喉咽合剂  高效液相色谱  指纹图谱  质量控制
英文关键词: Qinghouyan mixture  High performance liquid chromatography(HPLC)  Fingerprint  Control
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作者单位E-mail
姜范成 大连市检验检测认证技术服务中心 578682759@qq.com 
梁云 大连市检验检测认证技术服务中心  
鄢长余 大连市检验检测认证技术服务中心  
赵月然 大连市检验检测认证技术服务中心  
孙睿 大连市食品药品安全投诉举报受理中心  
刘莹 大连市食品药品安全投诉举报受理中心  
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中文摘要:
      目的:建立清喉咽合剂高效液相色谱指纹图谱分析方法,为其科学鉴定和质量控制提供依据。方法:色谱柱为ZORBAX SB-C18(4.6 mm×250 mm,5 μm);流动相为乙腈-3%醋酸水溶液梯度洗脱;流速1.0 mL·min-1;检测波长270 nm;柱温30 ℃。结果:清喉咽合剂色谱峰得到了较好的分离,建立了清喉咽合剂指纹图谱共有模式,确定了19个共有指纹峰、7个特征峰及所有色谱峰的分布情况。结论:该方法简便、重复性好、可操作性强,可用于建立清喉咽合剂指纹图谱质量标准和清喉咽合剂质量控制。
英文摘要:
      Objective:To establish a high performance liquid chromatographic fingerprint analysis method for Qinghouyan mixture, and provide evidence for its scientific identification and quality control. Methods:The column was ZORBAX SB-C18(4.6 mm×250 mm, 5 μm). The mobile phase was gradient elution with acetonitrile-3% acetic acid solution. The flow rate was 1.0 mL·min-1. The detection wavelength was 270 nm. The column temperature was 30 ℃. Results:The chromatographic peaks of Qinghouyan mixture were well separated. The common pattern of fingerprints of Qinghouyan mixture was established. The distribution of 19 common fingerprint peaks, 7 characteristic peaks and all chromatographic peaks were determined. Conclusion:The method is simple, reproducible and operability, and can be used to establish the quality standard of Qinghouyan mixture and the quality control of Qinghouyan mixture.
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