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文章摘要
.Indirect Comparison Meta-analysis of the Efficacy of Oral Medicine in the Treatment of Radiation-induced Esophagitis[J].中国药物评价,2019,36(3):230-235
口服药治疗放射性食管炎有效率的间接比较Meta分析
Indirect Comparison Meta-analysis of the Efficacy of Oral Medicine in the Treatment of Radiation-induced Esophagitis
投稿时间:2019-04-09  修订日期:2019-04-09
DOI:
中文关键词: 放射性食管炎  口服药  有效率  间接比较
英文关键词: Radiation-induced esophagitis  Oral drug  Effective  Indirect comparison
基金项目:甘肃省循证医学与临床转化重点实验室开放基金(项目编号:20180203;项目名称:循证中医药研究)
作者单位E-mail
施树珍 兰州大学基础医学院 循证医学中心 shishuzhen0@126.com 
刘明 兰州大学基础医学院 循证医学中心  
高亚 兰州大学基础医学院 循证医学中心  
马文娟 兰州大学基础医学院 循证医学中心  
邵丽华 兰州大学第一临床医学院  
王小虎 甘肃省肿瘤医院  
张秋宁 甘肃省肿瘤医院  
田金徽 兰州大学基础医学院 循证医学中心  
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中文摘要:
      目的:利用间接比较Meta分析方法评价18种口服药对放射性食管炎的影响。方法:计算机检索7个中英文数据库获取口服药治疗放射性食管炎的随机对照试验,并根据纳入和排除标准对相关文献进行筛选,对纳入的文献进行质量评价和数据信息提取,再利用STATA15.0和Excel 2010进行统计分析及制作网络证据图。结果:共纳入17篇随机对照试验。基于网络证据图和间接比较Meta分析结果可知:①复合维生素B溶液+庆大霉素+地塞米松、甘露醇+庆大霉素+地塞米松+利多卡因、甘露醇+庆大霉素+地塞米松和复合维生素B溶液形成的星状网络图中,复合维生素B溶液+庆大霉素+地塞米松有效率相对高;②思密达+普鲁卡因+庆大霉素+地塞米松、普鲁卡因+地塞米松+庆大霉素(含服)、思密达、普鲁卡因+氢化可的松、银翘青黛汤+思密达和甘露醇+维生素B12+庆大霉素+地塞米松形成的星状网络图中,甘露醇+维生素B12+庆大霉素+地塞米松(含服)可以提高有效率;③思密达+金因肽、利多卡因+庆大霉素+地塞米松+0.9%氯化钠注射液、玄参甘桔汤(泡饮)、康复新液和康复新+铝镁加混悬液形成的星状网络图中,玄参甘桔汤可以提高有效率;④双料喉风散、氢氧化铝凝胶和硝苯吡啶形成的星状网络图中,氢氧化铝凝胶有效率相对高。结论:基于间接比较结果,在地塞米松+庆大霉素基础上,联合使用维生素B12、甘露醇或复合维生素B溶液均在一定程度上可以提高有效率。另外,氢氧化铝凝胶和玄参甘桔汤也能有效缓解放射性食管炎的症状,建议未来开展直接比较研究以更加明确多种干预措施的疗效。
英文摘要:
      Objective: The effects of 18 oral medicines on radiation-induced esophagitis were evaluated by indirect comparison meta analysis. Methods: A total of 7 databases in Chinese and English were searched by computer to obtain the randomized controlled trials of oral administration for the radioactive esophagitis. Relevant literatures were screened according to inclusion and exclusion criteria, at the same time, the quality evaluation and data extraction were conducted for the included literatures. STATA 15.0 and Excel 2010 were used to analysis data and produce the figure of network evidence. Results: A total of 17 randomized controlled trials were included. Based on the results of network evidence graph and indirect comparison of meta-analysis ①A star-shaped network of “compound vitamin B solution + gentamicin+ dexamethasone”, “mannitol + gentamicin + dexamethasone + lidocaine”, “mannitol + gentamycin + dexamethasone” and “compound vitamin B solution” showed that “compound vitamin B solution + gentamicin+ dexamethasone” is the most efficient; ②A star-shaped network of “smecta + gentamicin + procaine + dexamethasone”, “gentamicin + procaine + dexamethasone”, “smecta”, “procaine + hydrocortisone”, “yinqiao qingdai decoction + smecta”, “mannitol + vitamin 12 + gentamicin + dexamethasone” showed that “mannitol + vitamin 12 + gentamicin + dexamethasone” may improve effectiveness; ③A star-shaped network of “smecta + genetime”, “xuanshenganjie decoction”, “lidocaine + gentamicin + dexamethasone + normal saline”, “kangfuxin solution”, “kangfuxin + aluminum magnesium plus suspension” showed that the “xuanshenganjie decoction” could improve the efficiency; ④A star-shaped network of “shuangliaohoufeng san + fresh egg white”, “aluminum hydroxide gel” and “nifidipine” showed that “aluminum hydroxide gel” was more effective than the other two oral drugs. Conclusion: Based on the results of comparison meta analysis, on the basis of dexamethasone and gentamicin, the combined use of vitamin B12 and compound vitamin B solution, or mannitol could improve the efficiency. In addition, there is evidence that aluminum hydroxide gel and traditional Chinese medicine xuanshenganjie decoction are also effective in the treatment of radiation-induced esophagitis, and direct comparison can be carried out in the future to further determine which intervention measures are better or worse.
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