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文章摘要
LI Pei-hu.Experimental Study on Bacteriostasis and Antiviral of Xiaoer Feire Kechuan Particles[J].中国药物评价,2019,36(4):289-293
小儿肺热咳喘颗粒抑菌抗病毒实验研究
Experimental Study on Bacteriostasis and Antiviral of Xiaoer Feire Kechuan Particles
投稿时间:2019-06-22  修订日期:2019-07-31
DOI:
中文关键词: 小儿肺热咳喘颗粒  抑菌  抗病毒  保护作用
英文关键词: Xiaoer Feire Kechuan Particles  Bacteriostatic  Antiviral  Protection
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作者单位E-mail
李培湖 海南葫芦娃药业集团股份有限公司 hklph@163.com 
刘全国 海南葫芦娃药业集团股份有限公司  
吴育强 海南葫芦娃药业集团股份有限公司 547663900@qq.com 
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中文摘要:
      目的:考察小儿肺热咳喘颗粒抑菌抗病毒作用,为临床应用提供依据。方法:采用体内抗病毒试验,体内外抑菌试验,考察药物的作用。结果:连续给药7d,小儿肺热咳喘颗粒 7.0、14.0 g生药·kg-1剂量组对甲型流感A/PR8/34病毒和乙型流感B/京防78-76病毒的感染具有明显的保护作用,显示出显著的抗病毒作用;体外抑菌试验,结果显示:小儿肺热咳喘颗粒对以上标准金黄色葡萄球菌、标准大肠杆菌、枯草芽孢杆菌、临床分离的大肠杆菌、肺炎双球菌、金黄色葡萄球菌、洋葱假单孢杆菌、表皮葡萄球菌、科代葡萄球菌均有一定的抑菌作用,抑菌圈范围为(10.5~14.5)mm;体内抑菌试验,连续给药7d,对金黄色葡萄球菌、肺炎双球菌感染小鼠有明显保护作用,显示有明显的抗菌作用。结论:小儿肺热咳喘颗粒具有明显的抑菌抗病毒作用。
英文摘要:
      Objective:To investigate the bacteriostatic and antiviral effects of Xiaoer Feire Kechuan Particles. Methods:In vivo antiviral test and in vivo and in vitro bacteriostatic test were used to investigate the effect of drugs. Results:After 7 days of continuous administration, Xiaoer Feire Kechuan Particles 7.0 and 14.0g raw drug·kg-1 dose group had obvious protective effect on influenza A/PR8/34 virus and influenza B virus infection, showing obvious antiviral effect;In vitro bacteriostatic test showed that:Xiaoer Feire Kechuan Particles to the above standard, staphylococcus aureus, escherichia coli, bacillus subtilis, e. coli clinical isolated, pneumonic diplococcus, staphylococcus aureus, onion false single spore bacilli, epidermis staphylococcus aureus, generation all have certain bacteriostatic action, bacteriostasis circle range (10.5~14.5) mm; In vivo bacteriostatic test, continuous administration for 7 days, the mice infected with staphylococcus aureus and pneumococci had obvious protective effect, showing obvious antibacterial effect. Conclusion:Xiaoer Feire Kechuan Particles have obvious antibacterial and antiviral effects.
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